The Ohio River is the largest tributary of the Mississippi River, at nearly 1,000 miles from its headwaters in Pittsburgh, Pennsylvania to its mouth on the Mississippi River at Cairo, Illinois. The Ohio flows through or along the border of six states including Pennsylvania, Ohio, West Virginia, Kentucky, Indiana and Illinois.
| Month | Number of Cruises | From Price |
|---|---|---|
| May 2026 | 1 cruises | $8,135 |
| Jul 2026 | 5 cruises | $5,275 |
| Jul 2027 | 3 cruises | $9,240 |
| Aug 2027 | 3 cruises | $9,240 |
| Jul 2028 | 2 cruises | $5,815 |
| Aug 2028 | 4 cruises | $5,815 |
| Sep 2028 | 3 cruises | $5,815 |
| 8 Night Ohio River Cruise and Land Tour from Pittsburgh | Duration | Priced from |
|---|---|---|
American Symphony 7 Sail Dates: 7/16/27; 7/27/27; 8/4/27; 8/12/27; 7/17/28; 7/25/28; 8/2/28; 8/10/28; 8/18/28; 8/26/28; See More Starting Port: Pittsburgh, Pennsylvania, United States Ports of Call: Pittsburgh, Wheeling, Marietta, Cruising the Ohio River, Cincinnati, Madison, Louisville |
8 Nights |
$5,815per person
(double occupancy) |
| 8 Night Ohio River Cruise and Land Tour from Pittsburgh | Duration | Priced from |
|---|---|---|
|
American Symphony 6 Sail Dates: 7/16/27; 7/27/27; 8/4/27; 8/12/27; 7/17/28; 7/25/28; 8/2/28; 8/10/28; 8/18/28; 8/26/28; See More Starting Port: Pittsburgh, Pennsylvania, United States Ports of Call: Pittsburgh, Wheeling, Marietta, Cruising the Ohio River, Cincinnati, Madison, Louisville |
8 Nights |
$5,815per person
(double occupancy) |
| 8 Night Ohio River Cruise and Land Tour from Louisville | Duration | Priced from |
|---|---|---|
American Heritage 4 Sail Dates: 7/2/26; 7/10/26; 7/17/26; 7/24/26; 7/31/26; 8/7/26; 8/14/26; See More Starting Port: Louisville, Kentucky, United States Ports of Call: Louisville, Cruising the Ohio River, Madison, Cincinnati, Cruising the Ohio River, Marietta... |
8 Nights |
$4,610per person
(double occupancy) |
| 11 Night Mississippi River Gateway Cruise and Land Tour from New Orleans | Duration | Priced from |
|---|---|---|
|
American Heritage 3 Sail Dates: 6/22/26; 6/29/27; 6/25/28; See More Starting Port: New Orleans, Louisiana, United States Ports of Call: New Orleans, Cruising the Mississippi River, Oak Alley, Cruising the Mississippi River, Vicksburg... |
11 Nights |
$6,360per person
(double occupancy) |
| 8 Night Ohio River Cruise and Land Tour from Louisville | Duration | Priced from |
|---|---|---|
|
American Heritage 3 Sail Dates: 7/2/26; 7/10/26; 7/17/26; 7/24/26; 7/31/26; 8/7/26; 8/14/26; See More Starting Port: Louisville, Kentucky, United States Ports of Call: Louisville, Cruising the Ohio River, Madison, Cincinnati, Cruising the Ohio River, Marietta... |
8 Nights |
$4,610per person
(double occupancy) |
| 15 Night Grand Ohio River Cruise and Land Tour from Pittsburgh | Duration | Priced from |
|---|---|---|
|
15 Nights |
$9,240per person
(double occupancy) |
| 8 Night Ohio River Cruise and Land Tour from Pittsburgh | Duration | Priced from |
|---|---|---|
|
American Melody 2 Sail Dates: 7/3/26; 7/10/26; 7/17/26; 7/24/26; See More Starting Port: Pittsburgh, Pennsylvania, United States Ports of Call: Pittsburgh, Wheeling, Marietta, Cruising the Ohio River, Cincinnati, Madison, Louisville |
8 Nights |
$5,275per person
(double occupancy) |
| 8 Night Ohio River Cruise and Land Tour from Pittsburgh | Duration | Priced from |
|---|---|---|
|
American Melody 2 Sail Dates: 7/3/26; 7/10/26; 7/17/26; 7/24/26; See More Starting Port: Pittsburgh, Pennsylvania, United States Ports of Call: Pittsburgh, Wheeling, Marietta, Cruising the Ohio River, Cincinnati, Madison, Louisville |
8 Nights |
$5,275per person
(double occupancy) |
