Ohio River Cruises and Discount Ohio River Cruise Vacations on iCruise.com

Ohio River Cruises

7 - 15 nights starting from $4,610 per person

The Ohio River is the largest tributary of the Mississippi River, at nearly 1,000 miles long.

The Ohio River is the largest tributary of the Mississippi River, at nearly 1,000 miles from its headwaters in Pittsburgh, Pennsylvania to its mouth on the Mississippi River at Cairo, Illinois. The Ohio flows through or along the border of six states including Pennsylvania, Ohio, West Virginia, Kentucky, Indiana and Illinois.

See less

Ohio River Calendar
Popular Ohio River

Month	Number of Cruises	From Price
May 2026	1 cruises	$8,135
Jul 2026	5 cruises	$5,275
Jun 2027	4 cruises	$6,299
Jul 2027	3 cruises	$8,725
Aug 2027	3 cruises	$9,240
Oct 2027	1 cruises	$12,998
Nov 2027	3 cruises	$5,999
Jul 2028	3 cruises	Call For Price
Aug 2028	4 cruises	Call For Price
Sep 2028	3 cruises	$9,240

14 Night Bayous Blues and Bluegrass Cruise from Louisville	Duration	Priced from
Viking Mississippi Viking River Cruises 2 Sail Dates: 6/1/27; 6/15/27; 10/26/27; 11/9/27; See More Starting Port: Louisville, Kentucky, United States Ending Port: New Orleans, Louisiana, United States Ports of Call: Louisville, Owensboro, Henderson, Paducah, Cruising the Mississippi River, Memphis, Greenville...	14 Nights	$11,498 per person (double occupancy)

14 Night Bayous Blues and Bluegrass Cruise from Louisville	Duration	Priced from
Viking Mississippi Viking River Cruises 2 Sail Dates: 6/1/27; 6/15/27; 10/26/27; 11/9/27; See More Starting Port: Louisville, Kentucky, United States Ending Port: New Orleans, Louisiana, United States Ports of Call: Louisville, Owensboro, Henderson, Paducah, Cruising the Mississippi River, Memphis, Greenville...	14 Nights	$11,498 per person (double occupancy)

7 Night Mississippi and Ohio River Explorer Cruise from Louisville	Duration	Priced from
Viking Mississippi Viking River Cruises 2 Sail Dates: 6/8/27; 6/15/27; 11/2/27; 11/9/27; See More Starting Port: Louisville, Kentucky, United States Ending Port: Memphis, Tennessee, United States Ports of Call: Louisville, Owensboro, Henderson, Paducah, Cruising the Mississippi River, Memphis	7 Nights	$5,999 per person (double occupancy)

7 Night Mississippi and Ohio River Explorer Cruise from Louisville	Duration	Priced from
Viking Mississippi Viking River Cruises 2 Sail Dates: 6/8/27; 6/15/27; 11/2/27; 11/9/27; See More Starting Port: Louisville, Kentucky, United States Ending Port: Memphis, Tennessee, United States Ports of Call: Louisville, Owensboro, Henderson, Paducah, Cruising the Mississippi River, Memphis	7 Nights	$5,999 per person (double occupancy)

8 Night Ohio River Cruise and Land Tour from Louisville	Duration	Priced from
American Heritage American Cruise Lines 4 Sail Dates: 7/2; 7/10; 7/17; 7/24; 7/31; 8/7; 8/14; See More Starting Port: Louisville, Kentucky, United States Ending Port: Pittsburgh, Pennsylvania, United States Ports of Call: Louisville, Cruising the Ohio River, Madison, Cincinnati, Cruising the Ohio River, Marietta...	8 Nights	$4,610 per person (double occupancy)

8 Night Ohio River Cruise and Land Tour from Louisville	Duration	Priced from
American Heritage American Cruise Lines 3 Sail Dates: 7/2; 7/10; 7/17; 7/24; 7/31; 8/7; 8/14; See More Starting Port: Louisville, Kentucky, United States Ending Port: Pittsburgh, Pennsylvania, United States Ports of Call: Louisville, Cruising the Ohio River, Madison, Cincinnati, Cruising the Ohio River, Marietta...	8 Nights	$4,610 per person (double occupancy)

15 Night Grand Ohio River Cruise and Land Tour from Pittsburgh	Duration	Priced from
American Melody American Cruise Lines 2 Sail Dates: 7/31; 7/16/27; See More Starting Port: Pittsburgh, Pennsylvania, United States Ending Port: St Louis, Missouri, United States Ports of Call: Pittsburgh, Cruising the Ohio River, Marietta, River Cruising, Maysville, Cincinnati, Madison...	15 Nights	$9,240 per person (double occupancy)

15 Night Grand Ohio River Cruise and Land Tour from Pittsburgh	Duration	Priced from
American Symphony American Cruise Lines 2 Sail Dates: 8/27/27; 9/26/28; See More Starting Port: Pittsburgh, Pennsylvania, United States Ending Port: St Louis, Missouri, United States Ports of Call: Pittsburgh, Cruising the Ohio River, Marietta, River Cruising, Maysville, Cincinnati, Madison...	15 Nights	$9,240 per person (double occupancy)

13 Night Mississippi and Ohio Rivers Cruise and Land Tour from New Orleans	Duration	Priced from
American Symphony American Cruise Lines 2 Sail Dates: 7/6/27; 7/4/28; See More Starting Port: New Orleans, Louisiana, United States Ending Port: Louisville, Kentucky, United States Ports of Call: New Orleans, Cruising the Mississippi River, Oak Alley, Baton Rouge, Cruising the Mississippi River...	13 Nights	$8,725 per person (double occupancy)

8 Night Ohio River Cruise and Land Tour from Pittsburgh	Duration	Priced from
American Melody American Cruise Lines 2 Sail Dates: 7/3; 7/10; 7/17; 7/24; See More Starting Port: Pittsburgh, Pennsylvania, United States Ending Port: Louisville, Kentucky, United States Ports of Call: Pittsburgh, Wheeling, Marietta, Cruising the Ohio River, Cincinnati, Madison, Louisville	8 Nights	$5,275 per person (double occupancy)

8 Night Ohio River Cruise and Land Tour from Pittsburgh	Duration	Priced from
American Melody American Cruise Lines 2 Sail Dates: 7/3; 7/10; 7/17; 7/24; See More Starting Port: Pittsburgh, Pennsylvania, United States Ending Port: Louisville, Kentucky, United States Ports of Call: Pittsburgh, Wheeling, Marietta, Cruising the Ohio River, Cincinnati, Madison, Louisville	8 Nights	$5,275 per person (double occupancy)

Ohio River Cruises

$11,498

$11,498

$5,999

$5,999

$4,610

$4,610

$9,240

$9,240

$8,725

$5,275

$5,275

X